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. 1976 Apr;76(2):249-56.
doi: 10.1017/s0022172400055145.

Mouse or man? Which are pertussis vaccines to protect?

N W Preston, T N Stanbridge

Mouse or man? Which are pertussis vaccines to protect?

N W Preston et al. J Hyg (Lond). 1976 Apr.

Abstract

Type 1 strains of Bordetella pertussis can infect mouse brain and have been recovered as type 1 organisms after death. When introduced into the naso-pharynx of the marmoset, they immediately acquired agglutinogen 2 or 3, and the resulting type 1,2 or 1,3 infection persisted for many weeks. As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas they are quite unnecessary in mouse brain. A vaccine (extract or whole cell) containing agglutinogen 1 may be sufficient to pass the mouse protection test but it may fail to immunize children. The mouse test is inadequate even for the screening of such extracts.

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