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. 1991;86(3):217-22.
doi: 10.1007/BF01250707.

The effect of methamphetamine on the release of glutamate from striatal slices

M L Earle  1 , J A Davies
Affiliations

The effect of methamphetamine on the release of glutamate from striatal slices

M L Earle et al. J Neural Transm Gen Sect. 1991.

Abstract

One postulated role of dopamine in the striatum is to reduce neuronal activity in cortico-striatal glutamergic terminals. We investigated the effects of methamphetamine, which displaces dopamine, on glutamate release from rat striatal slices. Methamphetamine significantly reduced K(+)-stimulated (45 mM) glutamate release. In slices prepared from rats treated 8 days previously with methamphetamine there was enhanced (approximately 200%) release of glutamate. This study demonstrates that dopamine has a modulatory effect on glutamate release in the striatum.

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