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Clinical Trial
. 1991 Sep;32(3):371-3.
doi: 10.1111/j.1365-2125.1991.tb03914.x.

Effects of H1-receptor blockade with terfenadine in nocturnal asthma

C Teale  1 , J F Morrison, S B Pearson
Affiliations
Clinical Trial

Effects of H1-receptor blockade with terfenadine in nocturnal asthma

C Teale et al. Br J Clin Pharmacol. 1991 Sep.

Abstract

1. In a single-blind placebo controlled study we have measured peak flow (PEFR) at 04.00 h and 16.00 h in eight asthmatics 6 h after placebo or terfenadine 120 mg, to determine if diurnal variation in histamine mediated effects contribute to nocturnal bronchoconstriction in asthma. 2. On placebo there was a significant diurnal variation in mean PEFR of 41 l min-1 (P less than 0.05). Terfenadine improved 04.00 h baseline mean PEFR from 242 to 278 l min-1 (P less than 0.05) but a 38 l min-1 diurnal variation in mean PEFR persisted (P less than 0.05). 3. We conclude that H1-receptor blockade with terfenadine may produce modest nocturnal bronchodilatation but does not influence the diurnal variation in PEFR in asthma suggesting that H1-receptor mediated effects are not important in the pathogenesis of nocturnal asthma.

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References

    1. BMJ. 1990 Sep 8;301(6750):473-6 - PubMed
    1. Br J Clin Pharmacol. 1988 Nov;26(5):515-25 - PubMed
    1. J Allergy Clin Immunol. 1985 Aug;76(2 Pt 2):375-80 - PubMed
    1. Br Med J (Clin Res Ed). 1988 May 21;296(6634):1427-9 - PubMed
    1. Br J Clin Pharmacol. 1987 Dec;24(6):743-6 - PubMed

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