[The role of covalent binding and lipid peroxidation in liver damage by carbon tetrachloride]
[Article in
Russian]
- PMID: 1777525
Item in Clipboard
[The role of covalent binding and lipid peroxidation in liver damage by carbon tetrachloride]
[Article in
Russian]
Biokhimiia.
1991 Oct.
Abstract
4-[N-sodium-N-(5-ethyl-1,3,4-thiadiazol-2-yl)]- sulphanylamido-5-methoxy-1,2-benzoquinone selectively inhibiting lipid peroxidation (LPO) was used to study the hepatotoxic effect of carbon tetrachloride in vivo. It was found that inactivation of the liver microsomal oxidation system during the first few hours after CCl4 injection is due to covalent binding rather than LPO.
Similar articles
-
Damage of rat liver microsomal mixed function oxidase system by carbon tetrachloride. In vivo study with selective inhibitor of lipid peroxidation.Biochem Int. 1991 Sep;25(2):349-53. Biochem Int. 1991. PMID: 1789798
-
4-(4-R-phenylamino)-5-methoxy-1,2-benzoquinones are new selective inhibitors of carbon tetrachloride-initiated free radical reactions in liver.Biochem Int. 1991 Sep;25(1):167-72. Biochem Int. 1991. PMID: 1772442
-
[Effect of o-benzoquinone derivatives on free radical processes, induced in rat liver microsomes by carbon tetrachloride].Biokhimiia. 1991 Jan;56(1):109-14. Biokhimiia. 1991. PMID: 1907503 Russian.
-
Chlorinated methanes and liver injury: highlights of the past 50 years.Annu Rev Pharmacol Toxicol. 2000;40:42-65. doi: 10.1146/annurev.pharmtox.40.1.43. Annu Rev Pharmacol Toxicol. 2000. PMID: 10836127 Review.
-
Toxicity of carbon tetrachloride, free radicals and role of antioxidants.Rev Environ Health. 2020 Sep 25;36(2):279-295. doi: 10.1515/reveh-2020-0048. Print 2021 Jun 25. Rev Environ Health. 2020. PMID: 32970608 Review.