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Clinical Trial
. 2007 Nov;51(11):4211-3.
doi: 10.1128/AAC.01087-07. Epub 2007 Sep 4.

Penetration of amphotericin B lipid formulations into pleural effusion

Stefan Weiler  1 , Rosa Bellmann-Weiler, Michael Joannidis, Romuald Bellmann
Affiliations
Clinical Trial

Penetration of amphotericin B lipid formulations into pleural effusion

Stefan Weiler et al. Antimicrob Agents Chemother. 2007 Nov.

Abstract

The penetration of the amphotericin B (AMB) lipid formulations (liposomal AMB, AMB colloidal dispersion, and AMB lipid complex formulations) into pleural effusions in seven critically ill patients was assessed. AMB was detected in all pleural effusion samples at concentrations ranging from 0.02 to 0.43 microg/ml. The penetration ratio was 3 to 44%.

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