Mechanism of action of the sex steroid hormones (first of three parts)
- PMID: 177871
- DOI: 10.1056/NEJM197606102942405
Mechanism of action of the sex steroid hormones (first of three parts)
Abstract
PIP: The mechanism of action of the sex steroid hormones is reviewed. Bi nding of steroid hormone (estrogen, progesterone, androgen) by target tissue, translocation of the hormone-receptor complex into the nucleus, hormone-receptor interactions with chromatin, and effects of the sex steroid hormones on chromatin structure are the main topics of discussio n. In general, after the steroid hormone is bound to a cytoplasmic receptor the transfer of the hormone-receptor complex into the target cell nucleus takes place. This is where the hormone exerts its influence on gene activity. Once the steroid-receptor complex moves into the nucleus it undergoes an interaction with the deoxyribonucleic acid-nucleoprotein complex of the cell nucleus that is often referred to as chromatin. The steroid hormone may exert its influence on gene function through this interaction. Current concepts of hormone action suggest that interaction of steroid hormones leads to increased ribonucleic acid synthesis and subsequently to protein synthesis.
Similar articles
-
Mechanism of action of the sex steroid hormones (second of three parts).N Engl J Med. 1976 Jun 17;294(25):1372-81. doi: 10.1056/NEJM197606172942505. N Engl J Med. 1976. PMID: 177874 Review.
-
[Action mechanism of sex steroid hormones].Nihon Rinsho. 1979 Jun 10;37(6):1218-26. Nihon Rinsho. 1979. PMID: 384049 Review. Japanese.
-
[Hormone receptors: theoretical and experimental aspects of the effect of steroid hormones].Wien Klin Wochenschr. 1983 May 27;95(11):382-4. Wien Klin Wochenschr. 1983. PMID: 6193649 German.
-
Actions of vertebrate sex hormones.Annu Rev Physiol. 1971;33:31-82. doi: 10.1146/annurev.ph.33.030171.000335. Annu Rev Physiol. 1971. PMID: 4157116 Review.
-
Current models of steroid hormone action: a critique.Annu Rev Physiol. 1976;38:425-50. doi: 10.1146/annurev.ph.38.030176.002233. Annu Rev Physiol. 1976. PMID: 176920 Review.
Cited by
-
Long-Term Exposure to Supraphysiological Levels of Testosterone Impacts Rat Submandibular Gland Proteome.Int J Mol Sci. 2023 Dec 31;25(1):550. doi: 10.3390/ijms25010550. Int J Mol Sci. 2023. PMID: 38203721 Free PMC article.
-
Investigations of serum testosterone levels in patients with laryngeal cancers.Arch Otorhinolaryngol. 1985;241(3):213-7. doi: 10.1007/BF00453690. Arch Otorhinolaryngol. 1985. PMID: 4026688
-
The effect of sex steroid hormones on the ecology of in vitro oral biofilms.Biofilm. 2023 Jun 29;6:100139. doi: 10.1016/j.bioflm.2023.100139. eCollection 2023 Dec 15. Biofilm. 2023. PMID: 37621393 Free PMC article.
-
Synthesis of apoprotein B of very low density lipoprotein in embryonic-chick liver. Development of responsiveness of oestrogen.Biochem J. 1980 Nov 15;192(2):733-40. doi: 10.1042/bj1920733. Biochem J. 1980. PMID: 7236235 Free PMC article.
-
Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance.Int J Mol Sci. 2022 Nov 4;23(21):13521. doi: 10.3390/ijms232113521. Int J Mol Sci. 2022. PMID: 36362304 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
