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. 1991 Dec;77(6):994-7.

Development of an in vitro microtest to assess drug susceptibility of Babesia bovis and Babesia bigemina

C R Brockelman  1 , P Tan-ariya
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  • PMID: 1779305

Development of an in vitro microtest to assess drug susceptibility of Babesia bovis and Babesia bigemina

C R Brockelman et al. J Parasitol. 1991 Dec.

Abstract

Continuous cultivation of the bovine hemoparasites Babesia bovis and Babesia bigemina was developed as an in vitro microtest to assess parasite susceptibility to babesicidal compounds. Reproducibility of parasite multiplication rates was independent of culture size, making it possible to use a microscale of 100 microliters for each test sample. Inhibitory concentrations (IC50s) of a commonly used babesicide, quinuronium sulfate, evaluated by this in vitro method were found to be 5 x 10(-8) g/ml for B. bovis and 2 x 10(-9) g/ml for B. bigemina.

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