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. 1961 Jul 28;134(3474):286-7.
doi: 10.1126/science.134.3474.286.

Possible Mode of Antidepressive Action of Imipramine

L Stein, J Seifter

Possible Mode of Antidepressive Action of Imipramine

L Stein et al. Science. .

Abstract

Imipramine augmented and prolonged methamphetamine-induced increases in the rate of responding of rats working for "rewarding" hypothalamic and midbrain stimulation. In contrast, chlorpromazine antagonized the effects of methamphetamine on self-stimulation. These opposite psychopharmacological effects are consistent with the different clinical effects of these drugs and suggest a mechanism for the antidepressive action of imipramine.

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