N-isopropyl-123I-p-iodoamphetamine uptake mechanism in the lung--is it dependent on pH, lipophilicity or pKa?
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- PMID: 1780245
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N-isopropyl-123I-p-iodoamphetamine uptake mechanism in the lung--is it dependent on pH, lipophilicity or pKa?
Nuklearmedizin.
1991 Dec.
Abstract
The uptake and binding mechanism of biogenic amines in the lungs has been studied extensively with no conclusive results. The competition between N-isopropyl-123I-p-iodo amphetamines (123I-IMP) and propranolol and 123I-IMP and ketamine, in the lungs suggest that the pKa value of the biogenic amines has a significant role to play in the mechanism of uptake and retention of biogenic amines in the lungs.
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