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. 1991 Dec;30(6):294-6.

N-isopropyl-123I-p-iodoamphetamine uptake mechanism in the lung--is it dependent on pH, lipophilicity or pKa?

S F Akber  1
Affiliations
  • PMID: 1780245

N-isopropyl-123I-p-iodoamphetamine uptake mechanism in the lung--is it dependent on pH, lipophilicity or pKa?

S F Akber. Nuklearmedizin. 1991 Dec.

Abstract

The uptake and binding mechanism of biogenic amines in the lungs has been studied extensively with no conclusive results. The competition between N-isopropyl-123I-p-iodo amphetamines (123I-IMP) and propranolol and 123I-IMP and ketamine, in the lungs suggest that the pKa value of the biogenic amines has a significant role to play in the mechanism of uptake and retention of biogenic amines in the lungs.

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