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. 2007 Oct 15;17(20):5548-51.
doi: 10.1016/j.bmcl.2007.08.024. Epub 2007 Aug 16.

Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries

Amanda J Krzysiak  1 , Sarah A Scott, Katherine A Hicks, Carol A Fierke, Richard A Gibbs
Affiliations

Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries

Amanda J Krzysiak et al. Bioorg Med Chem Lett. .

Abstract

Farnesylation, catalyzed by protein farnesyltransferase (FTase), is an important post-translational modification guiding cellular localization. Recently predictive models for identifying FTase substrates have been reported. Here we evaluate these models through screening of dansylated-GCaaS peptides, which also provides new insights into the protein substrate selectivity of FTase.

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Figures

Figure 1
Figure 1
Analysis of Dansyl-GCaaX peptides through screening.
Figure 2
Figure 2
Summary of FTase amino acid specificity.
See this image and copyright information in PMC

References

    1. Konstantinopoulos PA, Karamouzis MV, Papavassiliou AG. Nat Rev Drug Discov. 2007;6:541. - PubMed
    1. Basso AD, Kirschmeier P, Bishop WR. J Lipid Res. 2006;47:15. - PubMed
    1. Sebti SM, Der CJ. Nat Rev Cancer. 2003;3:945. - PubMed
    1. Reiss Y, Stradley S, Gierasch L, Brown M. Proc Natl Acad Sci U S A. 1991;88:732. - PMC - PubMed
    1. Moores SL, Schaber MD, Mosser SD, Rands E, O'Hara MB, Garsky VM, Marshall MS, Pompliano DL, Gibbs JB. J Biol Chem. 1991;266:14603. - PubMed

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