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. 1991;104(4):541-4.
doi: 10.1007/BF02245663.

Involvement of the amygdala in the memory-enhancing effects of clenbuterol

I B Introini-Collison  1 , B Miyazaki, J L McGaugh
Affiliations

Involvement of the amygdala in the memory-enhancing effects of clenbuterol

I B Introini-Collison et al. Psychopharmacology (Berl). 1991.

Abstract

Male Sprague Dawley rats with stria terminalis (ST) or sham lesions were trained in an inhibitory avoidance task, injected immediately post-training with clenbuterol hydrochloride (0.03 mg/kg; IP), and tested for retention 48 h later. Clenbuterol enhanced retention of the sham-lesioned animals but did not affect retention of the ST-lesioned animals. Clenbuterol injected intraamygdally immediately after training also enhanced retention of the inhibitory avoidance task. These results agree with other evidence suggesting the participation of beta-noradrenergic mechanisms in the amygdala in the modulation of memory storage.

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