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Review
. 2007 Dec;81(23):12720-9.
doi: 10.1128/JVI.01471-07. Epub 2007 Sep 5.

Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response

Robert H Silverman  1
Affiliations
Review

Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response

Robert H Silverman. J Virol. 2007 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
(A) The OAS/RNase L system, an innate immunity pathway that acts against viral infections. PPi, pyrophosphate; 2′PDE, 2′-phosphodiesterase; P'tase, phosphatase; IFN-R, IFN receptor. (B) Domain structure of human RNase L. (Copyright, The Cleveland Clinic Center for Medical Art & Photography; reproduced with permission.)
FIG. 2.
FIG. 2.
Antiviral effects of the cleavage of viral and cellular RNA substrates by RNase L.
See this image and copyright information in PMC

References

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    1. Banerjee, S., S. An, A. Zhou, R. H. Silverman, and S. Makino. 2000. RNase L-independent specific 28S rRNA cleavage in murine coronavirus-infected cells. J. Virol. 74:8793-8802. - PMC - PubMed
    1. Beattie, E., K. L. Denzler, J. Tartaglia, M. E. Perkus, E. Paoletti, and B. L. Jacobs. 1995. Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene. J. Virol. 69:499-505. - PMC - PubMed

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