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Clinical Trial
. 1991 Sep-Oct;85(5):670-1.
doi: 10.1016/0035-9203(91)90390-k.

Randomized treatment of patients with typhoid and paratyphoid fevers using norfloxacin or chloramphenicol

P S Sarma  1 , P Durairaj
Affiliations
Clinical Trial

Randomized treatment of patients with typhoid and paratyphoid fevers using norfloxacin or chloramphenicol

P S Sarma et al. Trans R Soc Trop Med Hyg. 1991 Sep-Oct.

Abstract

Forty adult patients with Salmonella typhi and S. paratyphi infections were studied in a randomly assigned prospective study to receive norfloxacin (12 drug-sensitive and 8 drug-resistant cases) or chloramphenicol (20 cases). No complication occurred in either group and no side effect was noted in the norfloxacin-treated group. The results suggest that a 7 d course of twice daily norfloxacin promises to be an alternative to a 14 d course of chloramphenicol for treating chloramphenicol-sensitive and multidrug-resistant typhoid and paratyphoid fevers.

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