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. 1980 Dec 19;210(4476):1347-9.
doi: 10.1126/science.210.4476.1347.

"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide

J N Pitts Jr, D M Lokensgard, P S Ripley, K A VAN Cauwenberghe, L VAN Vaeck, S D Shaffer, A J Thill, W L Belser Jr

"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide

J N Pitts Jr et al. Science. .

Abstract

Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.

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