Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2007 Sep 6;8(1):61.
doi: 10.1186/1465-9921-8-61.

Impaired cortical processing of inspiratory loads in children with chronic respiratory defects

Brigitte Fauroux  1 , Francis Renault, Pierre Yves Boelle, Christine Donzel-Raynaud, Frédéric Nicot, Annick Clément, Christian Straus, Thomas Similowski
Affiliations
Comparative Study

Impaired cortical processing of inspiratory loads in children with chronic respiratory defects

Brigitte Fauroux et al. Respir Res. .

Erratum in

  • Respir Res. 2008 Feb;9(1):22

Abstract

Background: Inspiratory occlusion evoked cortical potentials (the respiratory related-evoked potentials, RREPs) bear witness of the processing of changes in respiratory mechanics by the brain. Their impairment in children having suffered near-fatal asthma supports the hypothesis that relates asthma severity with the ability of the patients to perceive respiratory changes. It is not known whether or not chronic respiratory defects are associated with an alteration in brain processing of inspiratory loads. The aim of the present study was to compare the presence, the latencies and the amplitudes of the P1, N1, P2, and N2 components of the RREPs in children with chronic lung or neuromuscular disease.

Methods: RREPs were recorded in patients with stable asthma (n = 21), cystic fibrosis (n = 32), and neuromuscular disease (n = 16) and in healthy controls (n = 11).

Results: The 4 RREP components were significantly less frequently observed in the 3 groups of patients than in the controls. Within the patient groups, the N1 and the P2 components were significantly less frequently observed in the patients with asthma (16/21 for both components) and cystic fibrosis (20/32 and 14/32) than in the patients with neuromuscular disease (15/16 and 16/16). When present, the latencies and amplitudes of the 4 components were similar in the patients and controls.

Conclusion: Chronic ventilatory defects in children are associated with an impaired cortical processing of afferent respiratory signals.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Individual example of a patient with Duchenne muscular dystrophy showing the 4 components of the respiratory related evoked potential following inspiratory airway occlusion. Traces represent from top to bottom: left (C3-Cz) response, right (C4-Cz) response, and real time mouth pressure. S: onset of occlusion stimulus.
Figure 2
Figure 2
Individual example of a patient with congenital muscular dystrophy of unknown origin showing only the N1 component of the respiratory related evoked potential following inspiratory airway occlusion. The P1 component is not reproducible. Traces represent from top to bottom: left (C3-Cz) response, right (C4-Cz) response, and real time mouth pressure. S: onset of occlusion stimulus.
See this image and copyright information in PMC

References

    1. Davenport PW, Friedman WA, Thompson FJ, Franzen O. Respiratory-related cortical potentials evoked by inspiratory occlusions in humans. J Appl Physiol. 1986;60:1843–1848. - PubMed
    1. Davenport PW, Colrain IM, Hill PMN. Scalp topography of the short-latency components of the respiratory-related evoked potentials in children. J Appl Physiol. 1996;80:1786–1791. - PubMed
    1. Knafelc M. Relationship between resistive loads and P1 peak of respiratory-related evoked potential. J Appl Physiol. 1997;83:918–926. - PubMed
    1. Zhao W, Martin AD, Davenport PW. Respiratory-related evoked potentials elicited by inspiratory occlusions in double-lung transplant recipients. J Appl Physiol. 2002;93:894–902. - PubMed
    1. Daubenspeck JA, Manning HL, Akay M. Contribution of supraglottal mechanoreceptor afferents to respiratory-related evoked potentials in humans. J Appl Physiol. 2000;88:291–299. - PubMed

Publication types