Face familiarity feelings, the right temporal lobe and the possible underlying neural mechanisms

Abstract

A comprehensive review was made of the relationships between right hemisphere and face familiarity feelings, taking separately into account: (a) studies of patients with unilateral lesions of the anterior or the posterior parts of the right and left temporal lobes, who showed a familiar people recognition disorder, (b) studies of right and left brain-damaged patients, presenting an increased familiarity for unknown persons or abnormal familiarity feelings for well known people, (c) results of studies conducted in normal subjects to evaluate the lateralization of face familiarity feelings. In this last section, we separately reviewed: results obtained by means of separate presentation of familiar and unfamiliar faces to the right and left visual fields; lateralization of event-related potentials evoked by familiar vs unfamiliar faces; results of activation studies presenting familiar and unfamiliar faces. Taken together, results of this review have shown that face familiarity feelings are specifically generated by the right hemisphere. Clinical and neurophysiological data suggest that familiarity feelings: (1) are probably due to a lateralized subcortical route, allowing a first, unconscious, global recognition of familiar faces and (2) facilitate the subsequent distinction of known faces (unconsciously detected) from unfamiliar faces. Results of the review have also shown that the right frontal areas play an important role in the production or monitoring of inappropriate familiarity decisions.