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Review
. 2008 Jan;90(1):131-55.
doi: 10.1016/j.biochi.2007.07.011. Epub 2007 Jul 24.

Targeting telomeres and telomerase

Anne De Cian  1 , Laurent Lacroix, Céline Douarre, Nassima Temime-Smaali, Chantal Trentesaux, Jean-François Riou, Jean-Louis Mergny
Affiliations
Review

Targeting telomeres and telomerase

Anne De Cian et al. Biochimie. 2008 Jan.

Abstract

Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology.

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