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. 2007 Nov 15;15(22):6868-75.
doi: 10.1016/j.bmc.2007.08.026. Epub 2007 Aug 23.

Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

Ahmed Kamal  1 , R Ramu, Venkatesh Tekumalla, G B Ramesh Khanna, Madan S Barkume, Aarti S Juvekar, Surekha M Zingde
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Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

Ahmed Kamal et al. Bioorg Med Chem. .

Abstract

A series of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as anticancer activity. Some of these molecules have shown significant anticancer activity in a number of cancer cell lines.

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