Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jan 1;637(1-2):111-7.
doi: 10.1016/j.mrfmmm.2007.07.007. Epub 2007 Jul 24.

Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired

Frederic Morel  1 , Monique Renoux, Philippe Lachaume, Serge Alziari
Affiliations

Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired

Frederic Morel et al. Mutat Res. .

Abstract

Mitochondrial DNA lesions cause numerous human diseases, and it is therefore important to identify the mechanisms whereby the mitochondrion repairs the damage. We have studied in cultured Drosophila cells the repair of bleomycin-induced double-strand breaks (DSBs) in mitochondrial DNA. Our results show that DSBs are repaired as rapidly and effectively in the mitochondria as in the nucleus. DNA repair is complete within 2h following bleomycin treatment, showing that Drosophila mitochondria have an effective system of DSB repair. The mechanism and mitochondrial proteins involved remain to be identified.

PubMed Disclaimer

Publication types

LinkOut - more resources