Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jan;57(1):86-93.
doi: 10.1016/j.brainresrev.2007.06.018. Epub 2007 Jul 27.

Zebrafish and motor control over the last decade

Joseph R Fetcho  1 , Shin-ichi Higashijima, David L McLean
Affiliations
Review

Zebrafish and motor control over the last decade

Joseph R Fetcho et al. Brain Res Rev. 2008 Jan.

Abstract

The combination of transparency and accessible genetics is making zebrafish an increasingly important model in studies of motor control. Much of the work on the model has been done over the past decade. Here we review some of the highlights of this work that serve to reveal both the power of the model and its prospects for providing important future insights into the links between neural networks and behavior.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Imaging structure and function in vivo with genetic tools
A. Confocal image showing detailed morphology from an intact living fish of an ascending interneuron labeled with GFP under control of the promoter for the engrailed-1 gene, which is expressed in ascending inhibitory interneurons in zebrafish. The view is a lateral view with the head to the left. B. Two ascending interneurons expressing the genetic calcium indicator cameleon 2.1 under control of the engrailed-1 promoter. The calcium response of the neuron marked by the asterisk is shown in C during a swimming episode that begins at the break in the plot. The neurons are active duringswimming, as indicated by the fluorescence ratio increase.
See this image and copyright information in PMC

References

    1. Anichtchik OV, et al. Neurochemical and behavioural changes in zebrafish Danio rerio after systemic administration of 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurochem. 2004;88:443–53. - PubMed
    1. Banghart M, et al. Light-activated ion channels for remote control of neuronal firing. Nat Neurosci. 2004;7:1381–6. - PMC - PubMed
    1. Becker T, et al. Readiness of zebrafish brain neurons to regenerate a spinal axon correlates with differential expression of specific cell recognition molecules. J Neurosci. 1998;18:5789–803. - PMC - PubMed
    1. Becker T, et al. Axonal regrowth after spinal cord transection in adult zebrafish. Journal of Comparative Neurology. 1997;377:577–95. - PubMed
    1. Bernhardt RR, et al. Identification of spinal neurons in the embryonic and larval zebrafish. J Comp Neurol. 1990;302:603–616. - PubMed

Publication types