Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Sep;17(5):156-60.
doi: 10.2188/jea.17.156.

The hOGG1 Ser326Cys polymorphism is not associated with colorectal cancer risk

Hye-Won Park  1 , Il-Jin Kim, Hio Chung Kang, Sang-Geun Jang, Sun-A Ahn, Jin Soo Lee, Hai-Rim Shin, Jae-Gahb Park
Affiliations

The hOGG1 Ser326Cys polymorphism is not associated with colorectal cancer risk

Hye-Won Park et al. J Epidemiol. 2007 Sep.

Abstract

Background: Little is known about the genetic risk factors associated with colorectal cancer. Although the Ser326Cys polymorphism of 8-oxoguanine DNA glycosylase (hOGG1) is consistently associated with a range of cancers, there is no consensus regarding this polymorphism and colorectal cancer risk.

Methods: In the present study, conducted in a Korean population, we used the TaqMan assay to investigate whether the hOGG1 Ser326Cys polymorphism was associated with colorectal cancer in 439 colorectal cancer patients and 676 healthy normal controls. We also examined whether the hOGG1 Ser326Cys polymorphism is associated with tumor location, microsatellite instability (MSI) status and tumor-node-metastasis (TNM) stage in colorectal cancer.

Results: We found no significant difference between the cancer and control populations in terms of genotype distribution (CC, CG and GG). In addition, we found no association between the hOGG1 Ser326Cys polymorphism and cancer risk, MSI status, TNM stage or tumor location in colorectal cancer patients.

Conclusions: These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Misra RR, Ratnasinghe D, Tangrea JA, Virtamo J, Andersen MR, Barrett M, et al. . Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland. Cancer Lett 2003; 191: 171-8. 10.1016/S0304-3835(02)00638-9 - DOI - PubMed
    1. Lindahl T, Wood RD. Quality Control by DNA Repair. Science 1999; 286: 1897-905. 10.1126/science.286.5446.1897 - DOI - PubMed
    1. Krokan HE, Standal R, Slupphaug G. DNA glycosylases in the base excision repair of DNA. Biochem J 1997; 325: 1-16. 10.1042/bj3250001 - DOI - PMC - PubMed
    1. Shinmura K, Yokota J.. The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis. Antioxid Redox Signal 2001; 3: 597-609. 10.1089/15230860152542952 - DOI - PubMed
    1. Naylor SL, Johnson BE, Minna JD, Sakaguchi AY. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer. Nature 1987; 329: 451-4. 10.1038/329451a0 - DOI - PubMed

Publication types

Substances