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Review
. 2008 Jul;97(7):2395-404.
doi: 10.1002/jps.21176.

Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms

M L Houchin  1 , E M Topp
Affiliations
Review

Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms

M L Houchin et al. J Pharm Sci. 2008 Jul.

Abstract

Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed.

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