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Review
. 1991 Dec;11(4):783-93.
doi: 10.1016/0888-7543(91)90001-u.

Yeast artificial chromosome-based genome mapping: some lessons from Xq24-q28

D Schlessinger  1 , R D Little, D Freije, F Abidi, I Zucchi, G Porta, G Pilia, R Nagaraja, S K Johnson, J Y Yoon, A Srivastava, J Kere, G Palmieri, A Ciccodicola, V Montanaro, G Romano, A Casamassimi, M D'Urso
Affiliations
Review

Yeast artificial chromosome-based genome mapping: some lessons from Xq24-q28

D Schlessinger et al. Genomics. 1991 Dec.

Abstract

Yeast artificial chromosomes (YACs) have recently provided a potential route to long-range coverage of complex genomes in contiguous cloned DNA. In a pilot project for 50 Mb (1.5% of the human genome), a variety of techniques have been applied to assemble Xq24-q28 YAC contigs up to 8 Mb in length and assess their quality. The results indicate the relative strength of several approaches and support the adequacy of YAC-based methods for mapping the human genome.

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