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. 1945 Jan 19;101(2612):67-8.
doi: 10.1126/science.101.2612.67.

INTERACTION BETWEEN CRYSTALLINE PENICILLIN AND HUMAN PLASMA PROTEINS

B F Chow, C M McKee

INTERACTION BETWEEN CRYSTALLINE PENICILLIN AND HUMAN PLASMA PROTEINS

B F Chow et al. Science. .

Abstract

Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin.

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