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Review
. 1991 Sep;16(9):1031-6.
doi: 10.1007/BF00965847.

Some metabolic relationships between biopterin and folate: implications for the "methyl trap hypothesis"

S Kaufman  1
Affiliations
Review

Some metabolic relationships between biopterin and folate: implications for the "methyl trap hypothesis"

S Kaufman. Neurochem Res. 1991 Sep.

Abstract

Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide an escape from the "methyl trap."

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