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Review
. 1991 Sep;16(9):1055-8.
doi: 10.1007/BF00965850.

Fluoroacetate and fluorocitrate: mechanism of action

D D Clarke  1
Affiliations
Review

Fluoroacetate and fluorocitrate: mechanism of action

D D Clarke. Neurochem Res. 1991 Sep.

Abstract

The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.

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References

    1. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4942-6 - PubMed
    1. J Neurochem. 1987 May;48(5):1377-85 - PubMed
    1. Adv Enzymol Relat Areas Mol Biol. 1983;55:197-289 - PubMed
    1. Biochemistry. 1982 May 25;21(11):2637-44 - PubMed
    1. Biochem Biophys Res Commun. 1973 Dec 19;55(4):1197-207 - PubMed

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