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. 2007 Dec;51(12):4515-7.
doi: 10.1128/AAC.00416-07. Epub 2007 Sep 10.

Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China

Ruiru Shi  1 , Jianyuan Zhang, Koji Otomo, Guolong Zhang, Isamu Sugawara
Affiliations

Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China

Ruiru Shi et al. Antimicrob Agents Chemother. 2007 Dec.

Abstract

Seventy-four Mycobacterium tuberculosis clinical isolates from China were subjected to drug susceptibility testing using ethambutol, isoniazid, rifampin, and ofloxacin. The results revealed that the presence of embB mutations did not correlate with ethambutol resistance but was associated with multiple-drug resistance, especially resistance to both ethambutol and rifampin.

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Figures

FIG. 1.
FIG. 1.
embB DHPLC pattern of six EMB-susceptible isolates from Henan Province, China. I, isoniazid; R, rifampin; S, streptomycin; E, EMB; +, resistant; −, susceptible.
FIG. 2.
FIG. 2.
Distribution of embB mutation rates among isolates at different EMB concentrations. White bars indicate the embB mutation rates, and shaded bars show the multidrug resistance rates among isolates for each EMB MIC. Numbers inside the bars represent numbers of embB-mutated (or multidrug-resistant) isolates relative to the total number of isolates at each MIC.
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