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. 2007 Nov;51(11):4171-3.
doi: 10.1128/AAC.01480-06. Epub 2007 Sep 10.

Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-beta-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005

Jerneja Ambrozic Avgustin  1 , Rok Keber, Katja Zerjavic, Toni Orazem, Miklavz Grabnar
Affiliations

Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-beta-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005

Jerneja Ambrozic Avgustin et al. Antimicrob Agents Chemother. 2007 Nov.

Abstract

Seventy-four nonrepetitive uropathogenic fluoroquinolone-resistant or -intermediate extended-spectrum-beta-lactamase-producing Klebsiella isolates from Slovenia were screened for the presence of plasmid-mediated quinolone resistance genes. None of the known qnr genes were detected. The aac(6')-Ib-cr allele was detected on plasmids from 25 transconjugants for which the ciprofloxacin MIC was higher than for the recipient Escherichia coli strain.

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Figures

FIG. 1.
FIG. 1.
Plasmid restriction patterns of PstI-digested plasmids isolated from TK1 to TK25. Transconjugant designations are above the lanes; the molecular weight marker in lanes 1 of both panels A and B was the improved Gene Ruler 1-kb DNA ladder (Fermentas UAB, Lithuania).
See this image and copyright information in PMC

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