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. 2007 Oct 11;9(21):4295-8.
doi: 10.1021/ol7018532. Epub 2007 Sep 13.

Enantioselective Pd-catalyzed allylic alkylation of indoles by a new class of chiral ferrocenyl P/S ligands

Hong Yee Cheung  1 , Wing-Yiu Yu, Fuk Loi Lam, Terry T-L Au-Yeung, Zhongyuan Zhou, Tak Hang Chan, Albert S C Chan
Affiliations

Enantioselective Pd-catalyzed allylic alkylation of indoles by a new class of chiral ferrocenyl P/S ligands

Hong Yee Cheung et al. Org Lett. .

Abstract

Chiral ferrocenyl heterobidentate P/S ligands bearing both central and planar chirality were prepared from (S)-Ugi's amine via a three-step modular synthesis. Through systematic screening and optimization, L8 was found to be the best ligand for Pd-catalyzed asymmetric allylic alkylation of indoles with ee's up to 96% being attained.

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