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. 2007 Mar 17;12(3):536-42.
doi: 10.3390/12030536.

New cytotoxic steroid from Stachyurus imalaicus var. himalaicus

Yun-Song Wang  1 , Jing-Hua Yang, Shi-De Luo, Hong-Bin Zhang, Liang Li
Affiliations

New cytotoxic steroid from Stachyurus imalaicus var. himalaicus

Yun-Song Wang et al. Molecules. .

Abstract

A phytochemical study of the ethanolic extract of Stachyurus imalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 microg/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.

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Figures

Figure 1
Figure 1
Structures of compounds 1,2,3 and 4.
Figure 2
Figure 2
Partial MS analysis of 1.
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