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. 2007 Mar 17;12(3):536-42.
doi: 10.3390/12030536.

New cytotoxic steroid from Stachyurus imalaicus var. himalaicus

Yun-Song Wang  1 , Jing-Hua Yang, Shi-De Luo, Hong-Bin Zhang, Liang Li
Affiliations

New cytotoxic steroid from Stachyurus imalaicus var. himalaicus

Yun-Song Wang et al. Molecules. .

Abstract

A phytochemical study of the ethanolic extract of Stachyurus imalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 microg/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus.

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Figures

Figure 1
Figure 1
Structures of compounds 1,2,3 and 4.
Figure 2
Figure 2
Partial MS analysis of 1.
See this image and copyright information in PMC

References

    1. Li H., Hatano T., Okuda T., Yoshida T. Tannins of Stachyurus species. III. Stachyuranins A, B, and C, three new complex tannins from stachyurus praecox leaves. Chem. Pharm. Bull. 1995;43:2109–2114. doi: 10.1248/cpb.43.2109. - DOI
    1. Hatano T., Yazaki K., Okonogi A., Okuda T. Tannins of Stachyurus species. II. Praecoxins A, B, C and D, four new hydrolysable tannins from Stachyurus praecox leaves. Chem. Pharm. Bull. 1991;39:1689–1693. doi: 10.1248/cpb.39.1689. - DOI
    1. Institutum Botanicum Kunmingense Academiae Sinicae Edita . Flora Yunnanica. Science Press; Beijing: 1983. p. 339. Tomus 3. (in Chinese)
    1. Yang J.H., Wang Y.S., Huang R., Luo S.D., Zhang H.B., Li L. New polyoxygenated triterpenoids from Stachyurus himalaicus var. himalaicus. Helv. Chimi. Acta. 2006;89:2830–2835. doi: 10.1002/hlca.200690254. - DOI
    1. Wozny M. E.E., Smith T.R., Angus R.L., Kaiser E.T. Transformation pf 25-hydroxycholesterol by Rhizoctonia muneratii. Appl. Environ. Microbiol. 1982;3:572–577. - PMC - PubMed

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