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. 2007 Apr 17;12(4):782-96.
doi: 10.3390/12040782.

Complexes of 3d(n) metal ions with thiosemicarbazones: synthesis and antimicrobial activity

Tudor Rosu  1 , Aurelian Gulea, Anca Nicolae, Rodica Georgescu
Affiliations

Complexes of 3d(n) metal ions with thiosemicarbazones: synthesis and antimicrobial activity

Tudor Rosu et al. Molecules. .

Abstract

The chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-R-tricyclo[7.3.1.0.(2,7)]tridecane-13-one (where R = H, CH3, C6H5) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways--neutral bidentate or mononegative bidentate--depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand. The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.

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Figures

Figure 1
Figure 1
The structures of the ligands ( LH, LCH3, LC6H5).
Figure 2
Figure 2
Figure 3
Figure 3
Electronic spectra of Co(LH)2]Cl2, (A) and [Co(LR)2], (B) complexes.
Scheme 1
Scheme 1
Scheme 2
Scheme 2
Figure 4
Figure 4
ESR for complexes 1 and 2 in pyridine at 77K.
Figure 5
Figure 5
Figure 6
Figure 6
Graphical representation of the MIC values (mg/mL) of the tested compounds towards different bacterial strains.
See this image and copyright information in PMC

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