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. 2007 Apr 18;12(4):805-14.
doi: 10.3390/12040805.

Molecularly imprinted polymers for 5-fluorouracil release in biological fluids

Francesco Puoci  1 , Francesca Iemma, Giuseppe Cirillo, Nevio Picci, Pietro Matricardi, Franco Alhaiqu
Affiliations

Molecularly imprinted polymers for 5-fluorouracil release in biological fluids

Francesco Puoci et al. Molecules. .

Abstract

The aim of this work was to investigate the possibility of employing Molecularly Imprinted Polymers (MIPs) as a controlled release device for 5-fluorouracil (5-FU) in biological fluids, especially gastrointestinal ones, compared to Non Imprinted Polymers (NIPs). MIPs were synthesized using methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent. The capacity of the polymer to recognize and to bind the template selectively in both organic and aqueous media was evaluated. An in vitro release study was performed both in gastrointestinal and in plasma simulating fluids. The imprinted polymers bound much more 5-Fu than the corresponding non-imprinted ones and showed a controlled/sustained drug release, with MIPs release rate being indeed much more sustained than that obtained from NIPs. These polymers represent a potential valid system for drug delivery and this study indicates that the selective binding characteristic of molecularly imprinted polymers is promising for the preparation of novel controlled release drug dosage form.

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Figures

Figure 1
Figure 1
Schematic representation of the molecular imprinting process (T = Template; 1 = Assembly; 2 = Polymerization; 3 = Template Extraction).
Figure 2
Figure 2
a) 5-FU, b) uracil.
Figure 3
Figure 3
Schematic representation of 5-FU imprinting process.
Figure 4
Figure 4
Release profile of 5-FU from MIP-3 and NIP-3 in gastrointestinal simulating fluids.
Figure 5
Figure 5
Release profile of 5-FU from MIP-3 and NIP-3 in plasma simulating fluids.
See this image and copyright information in PMC

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