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. 2007 Apr 23;12(4):832-41.
doi: 10.3390/12040832.

Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum

Lin Zhang  1 , Zhen-Huan Liu, Jing-Kui Tian
Affiliations

Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum

Lin Zhang et al. Molecules. .

Abstract

Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23alpha-tetrahydroxyoleanane-28(13)-lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.

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Figures

Figure 1
Figure 1
Structures of compounds 1 and 2.
Figure 2
Figure 2
Key correlations in the 1H-1H COSY and NOESY spectra of 1.
Figure 3
Figure 3
Key correlations in the HMBC spectrum of 1.
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