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Clinical Trial
. 2008 Jun;21(3):273-6.
doi: 10.1007/s10534-007-9116-5. Epub 2007 Sep 13.

Non-transferrin-bound iron in plasma following administration of oral iron drugs

Bernd Dresow  1 , Doerte Petersen, Roland Fischer, Peter Nielsen
Affiliations
Clinical Trial

Non-transferrin-bound iron in plasma following administration of oral iron drugs

Bernd Dresow et al. Biometals. 2008 Jun.

Abstract

Non-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with normal iron stores or from patients with iron deficiency anaemia after oral application of pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up to 9 muM were found within the time period of 1-4 h after administration whereas transferrin saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but still measurable NTBI values. The physiological relevance of this finding for patients under iron medication has to be elucidated.

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