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Comment
. 2007 Oct;127(10):2295-6.
doi: 10.1038/sj.jid.5700939.

Recessive dystrophic epidermolysis bullosa-associated squamous-cell carcinoma: an enigmatic entity with complex pathogenesis

Ulrich Rodeck  1 , Jouni Uitto
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Free article
Comment

Recessive dystrophic epidermolysis bullosa-associated squamous-cell carcinoma: an enigmatic entity with complex pathogenesis

Ulrich Rodeck et al. J Invest Dermatol. 2007 Oct.
Free article

Abstract

Expression of either collagen VII or the noncollagenous (NC1) fragment derived from it has been suggested to be indispensable for the development of squamous-cell carcinomas (SCCs) in patients affected by recessive dystrophic epidermolysis bullosa (RDEB). This view is challenged here by the observation that SCCs do develop in RDEB patients lacking expression of collagen VII altogether. The aggressive behavior of RDEB-associated SCCs remains unexplained.

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