Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Sep;177(2):103-7.
doi: 10.1016/j.cancergencyto.2007.06.010.

TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors

Ahmed Idbaih  1 , Blandine Boisselier, Yannick Marie, Soufiane El Hallani, Marc Sanson, Emmanuelle Crinière, Mathieu Rodero, Catherine Carpentier, Sophie Paris, Florence Laigle-Donadey, François Ducray, Khê Hoang-Xuan, Jean-Yves Delattre
Affiliations

TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors

Ahmed Idbaih et al. Cancer Genet Cytogenet. 2007 Sep.

Abstract

The functional single-nucleotide polymorphism (SNP) in codon 72 of TP53 has been shown to be both a risk factor and a prognostic biomarker in various cancers. Such results were also reported in brain tumors, notably in astrocytomas. This SNP has never been precisely investigated in oligodendroglial tumors. We retrospectively analyzed blood samples of 275 oligodendroglial tumor patients for the TP53 codon 72 polymorphism and compared them with a series of 144 healthy controls. Arg/Arg, Arg/Pro, and Pro/Pro genotypes were found in 54.2 versus 60.4%, 39.3 versus 34.0%, and 7.3 versus 5.6% of patients and controls, respectively. This suggests no association between oligodendroglial tumors and the SNP in codon 72 of TP53. Similarly, no correlation was found among the TP53 codon 72 polymorphism and prognosis, p53 expression, and chromosomes 1p and 19q status.

PubMed Disclaimer

MeSH terms