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Comment

. 2007 Sep 18;104(38):14887-8.

doi: 10.1073/pnas.0707410104. Epub 2007 Sep 12.

Sweet taste signaling in the gut

Anthony Sclafani¹

Affiliations

PMID: 17855558
PMCID: PMC1986582
DOI: 10.1073/pnas.0707410104

Comment

Sweet taste signaling in the gut

Anthony Sclafani. Proc Natl Acad Sci U S A. 2007.

. 2007 Sep 18;104(38):14887-8.

doi: 10.1073/pnas.0707410104. Epub 2007 Sep 12.

Author

Anthony Sclafani¹

Affiliation

¹ Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA. asclafani@gc.cuny.edu

PMID: 17855558
PMCID: PMC1986582
DOI: 10.1073/pnas.0707410104

No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1. — Fig. 1.
T1R2+T1R3 sweet taste receptors are found in taste cells in the mouth and enteroendocrine cells in the gut. Stimulation of the T1R2+T1R3 receptors in the mouth by sugars and artificial sweeteners activates intracellular signaling elements, including α-gustducin (not shown), that trigger peripheral taste nerves and brain gustatory pathways. In the gut, stimulation of the T1R2+T1R3 receptors activates intracellular signaling elements, including α-gustducin (not shown), and causes the release of GLP-1 and GIP hormones. Among their many actions, these hormones stimulate the expression of SGLT1 in enterocytes, which, in turn, increases the absorption of glucose from the intestinal lumen.

See this image and copyright information in PMC

Comment on

T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.
Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. Margolskee RF, et al. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15075-80. doi: 10.1073/pnas.0706678104. Epub 2007 Aug 27. Proc Natl Acad Sci U S A. 2007. PMID: 17724332 Free PMC article.

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