Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2007 Sep 18;104(38):14887-8.
doi: 10.1073/pnas.0707410104. Epub 2007 Sep 12.

Sweet taste signaling in the gut

Anthony Sclafani  1
Affiliations
Comment

Sweet taste signaling in the gut

Anthony Sclafani. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
T1R2+T1R3 sweet taste receptors are found in taste cells in the mouth and enteroendocrine cells in the gut. Stimulation of the T1R2+T1R3 receptors in the mouth by sugars and artificial sweeteners activates intracellular signaling elements, including α-gustducin (not shown), that trigger peripheral taste nerves and brain gustatory pathways. In the gut, stimulation of the T1R2+T1R3 receptors activates intracellular signaling elements, including α-gustducin (not shown), and causes the release of GLP-1 and GIP hormones. Among their many actions, these hormones stimulate the expression of SGLT1 in enterocytes, which, in turn, increases the absorption of glucose from the intestinal lumen.
See this image and copyright information in PMC

Comment on

References

    1. Breslin PAS, Huang L. Adv Otorhinolaryngol. 2006;63:152–190. - PubMed
    1. Berthoud H-R. Neurosci Biobehav Rev. 2002;26:393–428. - PubMed
    1. Dyer J, Vayro S, King TP, Shirazi-Beechey SP. Eur J Biochem. 2003;270:3377–3388. - PubMed
    1. Raybould HE. Auton Neurosci. 2007;133:86–90. - PubMed
    1. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KSH, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. Proc Natl Acad Sci USA. 2007;104:15075–15080. - PMC - PubMed

LinkOut - more resources