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Review
. 2007 Sep 13;357(11):1113-20.
doi: 10.1056/NEJMct074213.

Low-tidal-volume ventilation in the acute respiratory distress syndrome

Atul Malhotra  1
Affiliations
Review

Low-tidal-volume ventilation in the acute respiratory distress syndrome

Atul Malhotra. N Engl J Med. .

Abstract

A 55-year-old man who is 178 cm tall and weighs 95 kg is hospitalized with community-acquired pneumonia and progressively severe dyspnea. His arterial oxygen saturation while breathing 100% oxygen through a face mask is 76%; a chest radiograph shows diffuse alveolar infiltrates with air bronchograms. He is intubated and receives mechanical ventilation; ventilator settings include a tidal volume of 1000 ml, a positive end-expiratory pressure (PEEP) of 5 cm of water, and a fraction of inspired oxygen (FiO2) of 0.8. With these settings, peak airway pressure is 50 to 60 cm of water, plateau airway pressure is 38 cm of water, partial pressure of arterial oxygen is 120 mm Hg, partial pressure of carbon dioxide is 37 mm Hg, and arterial blood pH is 7.47. The diagnosis of the acute respiratory distress syndrome (ARDS) is made. An intensive care specialist evaluates the patient and recommends changing the current ventilator settings and implementing a low-tidal-volume ventilation strategy.

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Figures

Figure 1
Figure 1. Normal Rat Lungs and Rat Lungs after Receiving High-Pressure Mechanical Ventilation at a Peak Airway Pressure of 45 cm of Water
After 5 minutes of ventilation, focal zones of atelectasis were evident, in particular at the left lung apex. After 20 minutes of ventilation, the lungs were markedly enlarged and congested; edema fluid filled the tracheal cannula. Adapted from Dreyfuss et al. with the permission of the publisher.
Figure 2
Figure 2. Conventional Ventilation as Compared with Protective Ventilation
This example of ventilation of a 70-kg patient with ARDS shows that conventional ventilation at a tidal volume of 12 ml per kilogram of body weight and an end-expiratory pressure of 0 cm of water (Panel A) can lead to alveolar overdistention (at peak inflation) and collapse (at the end of exhalation). Protective ventilation at a tidal volume of 6 ml per kilogram (Panel B) limits overinflation and end-expiratory collapse by providing a low tidal volume and an adequate positive end-expiratory pressure. Adapted from Tobin.
Figure 3
Figure 3. Effects of Recruitment Maneuvers to Promote Homogeneity within the Lung
Panels A through D show the progressive resolution of infiltrates after application of inflations of increasing pressure. Reprinted from Borges et al.
See this image and copyright information in PMC

Comment in

  • Low-tidal-volume ventilation.
    Chiche L, Forel JM, Papazian L. Chiche L, et al. N Engl J Med. 2007 Dec 13;357(24):2518-9; author reply 2519-20. doi: 10.1056/NEJMc072900. N Engl J Med. 2007. PMID: 18077819 No abstract available.
  • Low-tidal-volume ventilation.
    Asakura Y, Komatsu T. Asakura Y, et al. N Engl J Med. 2007 Dec 13;357(24):2519; author reply 2519-20. N Engl J Med. 2007. PMID: 18080385 No abstract available.
  • Low-tidal-volume ventilation.
    Busch T, Bercker S, Kaisers U. Busch T, et al. N Engl J Med. 2007 Dec 13;357(24):2519; author reply 2519-20. N Engl J Med. 2007. PMID: 18084817 No abstract available.

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