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Review
. 1976 Apr;17(4):285-8.
doi: 10.1136/gut.17.4.285.

Successful treatment of a malignant gastrinoma with streptozotocin

J R Hayes, N O'Connell, T O'Neill, J J Fennelly, D G Weir
Review

Successful treatment of a malignant gastrinoma with streptozotocin

J R Hayes et al. Gut. 1976 Apr.

Abstract

The treatment with streptozotocin of a patient with metastatic gastrinoma is described. Two courses of intravenous streptozotocin were without effect. However, three months after two doses of 4 g streptozotocin were given into the coeliac axis, there was a marked reduction in hepatic size and a fall in fasting plasma gastrin levels from 1430 pmol/l to 240 pmol/l. Seven months after treatment fasting plasma gastrin levels were 125 pmol/l.

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