doi: 10.1021/ol701669b.
Epub 2007 Sep 15.
Enantioselective formal [3+3] annulation for the direct construction of bicyclic skeletons with four stereogenic centers
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- PMID: 17867691
- DOI: 10.1021/ol701669b
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Enantioselective formal [3+3] annulation for the direct construction of bicyclic skeletons with four stereogenic centers
Org Lett.
.
Abstract
An enantioselective formal [3+3] annulation reaction of cyclic ketones with enones has been developed. In the presence of 20 mol % of pyrrolidine-thiourea 1a or N-(pyrrolidin-2-ylmethyl)trifluoromethanesulfonamide 1i, the reactions afford bicyclo [3.3.1] adducts in moderate to good yields with good to high enantioselectivities under mild conditions.
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