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. 2007 Oct 11;9(21):4155-8.
doi: 10.1021/ol7017328. Epub 2007 Sep 15.

Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition

Yizhong Wang  1 , Claudia I Rivera Vera, Qing Lin
Affiliations

Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition

Yizhong Wang et al. Org Lett. .

Abstract

A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield.

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