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Comment
. 2007 Sep 14;317(5844):1500; author reply 1500.
doi: 10.1126/science.1138179.

Comment on "The consensus coding sequences of human breast and colorectal cancers"

William F Forrest  1 , Guy Cavet
Affiliations
Comment

Comment on "The consensus coding sequences of human breast and colorectal cancers"

William F Forrest et al. Science. .

Abstract

Sjöblom et al. (Research Articles, 13 October 2006, p. 268) used data from cancer genome resequencing to identify genes with elevated mutation rates. Their analysis used point probabilities when it should have used P values for the hypotheses they intended to test. Reimplementing their analysis method with exact P values results in far fewer genes with mutation rates that achieve statistical significance.

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Comment on

  • The consensus coding sequences of human breast and colorectal cancers.
    Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. Sjöblom T, et al. Science. 2006 Oct 13;314(5797):268-74. doi: 10.1126/science.1133427. Epub 2006 Sep 7. Science. 2006. PMID: 16959974

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