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Comment
. 2007 Sep 14;317(5844):1500.
doi: 10.1126/science.1138764.

Comment on "The consensus coding sequences of human breast and colorectal cancers"

Gad Getz  1 , Holger Höfling, Jill P Mesirov, Todd R Golub, Matthew Meyerson, Robert Tibshirani, Eric S Lander
Affiliations
Comment

Comment on "The consensus coding sequences of human breast and colorectal cancers"

Gad Getz et al. Science. .

Abstract

Sjöblom et al. (Research Article, 13 October 2006, p. 268) reported nearly 200 novel cancer genes said to have a 90% probability of being involved in colon or breast cancer. However, their analysis raises two statistical concerns. When these concerns are addressed, few genes with significantly elevated mutation rates remain. Although the biological methodology in Sjöblom et al. is sound, more samples are needed to achieve sufficient power.

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Comment on

  • The consensus coding sequences of human breast and colorectal cancers.
    Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. Sjöblom T, et al. Science. 2006 Oct 13;314(5797):268-74. doi: 10.1126/science.1133427. Epub 2006 Sep 7. Science. 2006. PMID: 16959974

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