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. 2007 Oct;56(10):1333-6.
doi: 10.1136/gut.2006.115402.

The IL23 axis plays a key role in the pathogenesis of IBD

Dermot McGovern  1 , Fiona Powrie
Affiliations

The IL23 axis plays a key role in the pathogenesis of IBD

Dermot McGovern et al. Gut. 2007 Oct.

Abstract

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

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Conflict of interest statement

Competing interests: None.

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