The IL23 axis plays a key role in the pathogenesis of IBD

doi:10.1136/gut.2006.115402

. 2007 Oct;56(10):1333-6.

doi: 10.1136/gut.2006.115402.

The IL23 axis plays a key role in the pathogenesis of IBD

Dermot McGovern¹, Fiona Powrie

Affiliations

PMID: 17872562
PMCID: PMC2000291
DOI: 10.1136/gut.2006.115402

The IL23 axis plays a key role in the pathogenesis of IBD

Dermot McGovern et al. Gut. 2007 Oct.

. 2007 Oct;56(10):1333-6.

doi: 10.1136/gut.2006.115402.

Authors

Dermot McGovern¹, Fiona Powrie

Affiliation

¹ Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK. dermotmcgovern@doctors.net.uk

PMID: 17872562
PMCID: PMC2000291
DOI: 10.1136/gut.2006.115402

Abstract

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

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Conflict of interest statement

Competing interests: None.

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References

1. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 20033521–533. - PubMed
1. Simpson S J, Shah S, Comiskey M.et al T cell‐mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)‐4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 19981871225–1234. - PMC - PubMed
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1. Oppmann B, Lesley R, Blom B.et al Novel p19 protein engages IL‐12p40 to form a cytokine, IL‐23, with biological activities similar as well as distinct from IL‐12. Immunity 200013715–725. - PubMed
1. Yen D, Cheung J, Scheerens H.et al IL‐23 is essential for T cell‐mediated colitis and promotes inflammation via IL‐17 and IL‐6. J Clin Invest 20061161310–1316. - PMC - PubMed

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[1] Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 20033521–533. - PubMed

[2] Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 20033521–533. - PubMed

[3] Simpson S J, Shah S, Comiskey M.et al T cell‐mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)‐4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 19981871225–1234. - PMC - PubMed

[4] Simpson S J, Shah S, Comiskey M.et al T cell‐mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)‐4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 19981871225–1234. - PMC - PubMed

[5] Neurath M F, Fuss I, Kelsall B L.et al Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 19951821281–1290. - PMC - PubMed

[6] Neurath M F, Fuss I, Kelsall B L.et al Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 19951821281–1290. - PMC - PubMed

[7] Oppmann B, Lesley R, Blom B.et al Novel p19 protein engages IL‐12p40 to form a cytokine, IL‐23, with biological activities similar as well as distinct from IL‐12. Immunity 200013715–725. - PubMed

[8] Oppmann B, Lesley R, Blom B.et al Novel p19 protein engages IL‐12p40 to form a cytokine, IL‐23, with biological activities similar as well as distinct from IL‐12. Immunity 200013715–725. - PubMed

[9] Yen D, Cheung J, Scheerens H.et al IL‐23 is essential for T cell‐mediated colitis and promotes inflammation via IL‐17 and IL‐6. J Clin Invest 20061161310–1316. - PMC - PubMed

[10] Yen D, Cheung J, Scheerens H.et al IL‐23 is essential for T cell‐mediated colitis and promotes inflammation via IL‐17 and IL‐6. J Clin Invest 20061161310–1316. - PMC - PubMed

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The IL23 axis plays a key role in the pathogenesis of IBD

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The IL23 axis plays a key role in the pathogenesis of IBD

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