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Review
. 2007 Nov;6(11):1933-42.
doi: 10.1128/EC.00254-07. Epub 2007 Sep 14.

Multidrug resistance in fungi

Kailash Gulshan  1 , W Scott Moye-Rowley
Affiliations
Review

Multidrug resistance in fungi

Kailash Gulshan et al. Eukaryot Cell. 2007 Nov.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Multidrug resistance pathway in Saccharomyces cerevisiae. A general scheme describing key genetic interactions regulating pleiotropic drug resistance is shown. Standard arrows indicate positive interactions, while the blunt arrows denote negative regulation. The small gray boxes represent Pdr1p/Pdr3p response elements (PDREs), and the white boxes indicate Yrr1p response elements.
FIG. 2.
FIG. 2.
Interactions between the Pdr pathway and sphingolipid biosynthesis. An outline of the biosynthetic pathway producing sphingolipids is depicted. Arrows indicate enzymatic reactions. Genes encoding proteins involved in selected pathway reactions are shown. The black boxes denote genes that are believed to be regulated by Pdr1p and/or Pdr3p. Rsb1p can transport both DHS and PHS (56). M(IP)2C is mannosyl diinositolphospho-ceramide (31), the final product of the sphingolipid pathway in S. cerevisiae.
See this image and copyright information in PMC

References

    1. Alanis, A. J. 2005. Resistance to antibiotics: are we in the post-antibiotic era? Arch. Med. Res. 36:697-705. - PubMed
    1. Alarco, A. M., I. Balan, D. Talibi, N. Mainville, and M. Raymond. 1997. AP-1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J. Biol. Chem. 272:19304-19313. - PubMed
    1. Alarco, A. M., and M. Raymond. 1999. The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans. J. Bacteriol. 181:700-708. - PMC - PubMed
    1. Balzi, E., W. Chen, S. Ulaszewski, E. Capieaux, and A. Goffeau. 1987. The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J. Biol. Chem. 262:16871-16879. - PubMed
    1. Balzi, E., and A. Goffeau. 1995. Yeast Multidrug Resistance: the PDR network. J. Bioenerget. Biomembr. 27:71-76. - PubMed

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