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Comparative Study
. 2007 Nov;51(11):4191-5.
doi: 10.1128/AAC.00550-07. Epub 2007 Sep 17.

Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents

Tatiana Bogdanovich  1 , Catherine Clark, Klaudia Kosowska-Shick, Bonifacio Dewasse, Pamela McGhee, Peter C Appelbaum
Affiliations
Comparative Study

Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents

Tatiana Bogdanovich et al. Antimicrob Agents Chemother. 2007 Nov.

Abstract

Among 203 strains of Staphylococcus aureus, the MICs of CG400549 were 0.06 to 1.0 microg/ml, with MIC(50) and MIC(90) values of 0.25 microg/ml each. All strains were susceptible to linezolid and quinupristin-dalfopristin (MICs, 0.25 to 2.0 microg/ml). The daptomycin MICs were 0.25 to 2.0 microg/ml for methicillin-susceptible and 0.25 to 4.0 microg/ml against methicillin-resistant strains (including vancomycin-intermediate strains). Single-passage selection testing showed low resistance frequencies with CG400549, but multistep analysis showed that CG400549 yielded resistant mutants after 14 to 17 days in all strains tested.

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Figures

FIG. 1.
FIG. 1.
Structure of CG400549.
See this image and copyright information in PMC

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