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. 2007 Dec;51(12):4495-7.
doi: 10.1128/AAC.00753-07. Epub 2007 Sep 17.

Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis

Sean T Byrne  1 , Peihua Gu, Jiangbing Zhou, Steven M Denkin, Curtis Chong, David Sullivan, Jun O Liu, Ying Zhang
Affiliations

Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis

Sean T Byrne et al. Antimicrob Agents Chemother. 2007 Dec.

Abstract

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 microg/ml and 0.13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

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